HOME > mice > Col11a2-Smad6 mice

Strain Detail

Strain information
Resource No. nbio130
Strain name Col11a2-Smad6
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Bone and Cartilage Biology, Osaka University Graduate School of Medicine
Developer Noriyuki Tsumaki
Depositor Noriyuki Tsumaki
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

Col11a2-Smad6 mice are transgenic mice specifically expressing Smad6 in chondrocytes and become dwarfism with osteopenia. The transgene specifically regulated by using Col11a2 (Type XI collagen alpha 2 chain gene) promoter/enhancer in chondrocytes. It's showed that this srain is delayed hypertrophy of chondrocytes though chondrocyte growth is almost normal in the endochondral ossification. It's concidered that this event is related to disorder of bone growth and formation.

This strain is useful for elucidation of in vivo roles of Smad6 about signal transduction of bone morphogenetic protein (BMP) which is important of osteogenesis or chondrogenesis, and expects to contribute to basic research for the therapy of motor system diseases in orthopedics. Incidentally, Smad is a protein to transduce intracellular signal of growth differentiation factor in the TGF-β super family, and it's classified receptor-regulated Smad, common Smad, antagonistic Smad. Smad6 is an antagonistic Smad.

References
  1. Horiki M, Imamura T, Okamoto M, Hayashi M, Murai J, Myoui A, Ochi T, Miyazono K, Yoshikawa H, Tsumaki N. (2004) Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia. J Cell Biol. May 10;165(3):433-45. [PMID: 15123739]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Smad6
Gene name SMAD family member 6
Genotyping information