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Strain Detail: TIGAR KO mice

Strain information
Resource No. nbio362
Strain name TIGAR KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Cardiovascular Medicine, Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
Developer Satoaki Matoba
Depositor Satoaki Matoba
Conditions of distribution

Users shall give an acknowledgment to the depositor when publishing the research results.
Animal Health Report
Strain description

TP53-induced glycolysis and apoptosis regulator (TIGAR, a.k.a., Trp53 induced glycolysis regulatory phosphatase) modulates cardiac metabolism. The TIGAR KO mice are knockout mice for the Tigar gene and useful for analyzing the gene function in heart failure.　Mice for conditional KO are also available.
Reference(s)
  1. Okawa Y, Hoshino A, Ariyoshi M, Kaimoto S, Tateishi S, Ono K, Uchihashi M, Iwai-Kanai E, and Matoba S. (2019) Ablation of cardiac TIGAR preserves myocardial energetics and cardiac function in the pressure overload heart failure model. Am J Physiol Heart Circ Physiol 316: H1366-H1377. [PMID:30901275]
Resource information
Cryopreserved sperm In-house Genotype Heterozygous
Medium Fertiup
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype Mix of heterozygotes and wild-types
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Tigar
Gene name Trp53 induced glycolysis regulatory phosphatase
Genotyping information