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Strain Detail: Tmppe-KO mice

Strain information
Resource No. nbio416
Strain name Tmppe-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description Tmppe-WB

Our laboratory has used knockout (KO) mice (BKO) of the Glb1 gene as a mouse model for GM1 gangliosidosis. The intron of the Glb1 gene contains the Tmppe gene; however, little is known about the properties of Tmppe. Therefore, Tmppe KO mice were generated by removing the entire coding sequence of the Tmppe gene by gene editing using the CRISPR/Cas9 system. The KO mice lost their TMPPE protein expression (see Western blot figure) without any apparent abnormality. This strain is useful for the study of TMPPE protein function.

Resource information
Cryopreserved sperm In-house Genotype Heterozygous
Medium Fertiup
From other institutions Genotype
Cryopreserved embryo In-house Mating System Heterozyous x B6NCr Slc
Genotype Heterozygous or wild
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Tmppe
Gene name transmembrane protein with metallophosphoesterase domain
Genotyping information