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Strain Detail: Tomm5 KO mice
| Strain information |
| Resource No. |
nbio347 |
| Strain name |
Tomm5 KO |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6N |
| Institution |
Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition |
| Developer |
Osamu Suzuki |
| Depositor |
Osamu Suzuki |
| Conditions of distribution |
Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
|
| Strain description |
Mice in which the Tomm5 gene was knocked out by genome editing (CRISPR/Cas9). In this strain, part of the first exon was deleted by setting gRNA in exon 1. The product of the Tomm5 gene is present in the mitochondria and contributes to protein transport and has also been implicated in pulmonary fibrosis. This strain is useful for studying mitochondrial protein transport and pulmonary fibrosis. |
| Reference(s) |
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Heterozygous |
| Medium |
Fertiup |
| From other institutions |
Genotype |
|
| Medium |
|
| Cryopreserved embryo |
In-house |
Mating System |
Heterozyous x B6NCr Slc |
| Genotype |
Heterozygous or wild |
| Medium |
EFS40 |
| From other institutions |
Mating System |
|
| Genotype |
|
| Method |
|
| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Tomm5 |
| Gene name |
translocase of outer mitochondrial membrane 5 |
| Genotyping information |
|
