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Strain Detail: villin-CXCL12 Tg mice
| Strain information | |
|---|---|
| Resource No. | nbio317 |
| Strain name | villin-CXCL12 Tg |
| Strain Nomenclature | |
| Common name/Synonyms | |
| Strain types | mutant |
| Background strain | C57BL/6J |
| Institution | Kyorin University (1), and EA Pharma (2) |
| Developer | Tadakazu Hisamatsu （1）， and Uo Michihide （2） |
| Depositor | Tadakazu Hisamatsu （1）， and Uo Michihide （2） |
| Conditions of distribution | In publishing the research results obtained by use of the biological resource, the stipulation of an acknowledgment to depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. : contact us |
| Animal Health Report | |
| Strain description | Chronic inflamation characterized by infiltration of IgG-producing plasma cell into colonic mucosa is a histological hallmark of ulcerative coliteis. This infiltration is influenced by CXCL12-CXCR4 axis. CXCL12 is a CXC chemokine, which is involved in the chemoattraction of T cells. The strain is a transgenic mouse line that overexpresses mouse CXCL12 (SDF-1α) specifically in gastrointestinal epithelial cells under the control of mouse villin promoter. This strain is useful for functional stuideis of CXCL12 in the gastrointestinal epithelial cells. |
| Reference(s) | |
| Resource information | |||
|---|---|---|---|
| Cryopreserved sperm | In-house | Genotype | |
| Medium | |||
| From other institutions | Genotype | ||
| Medium | |||
| Cryopreserved embryo | In-house | Mating System | |
| Genotype | |||
| Medium | |||
| From other institutions | Mating System | ||
| Genotype | |||
| Method | |||
| Strain status / Availability | Cryopreserved sperm | ||
| Cryopreserved embryo | |||
| Live animals | |||
| Gene information | |
|---|---|
| Mutation types | transgenic |
| Gene symbol | Cxcl12 |
| Gene name | chemokine (C-X-C motif) ligand 12 |
| Genotyping information | |