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Strain Detail: villin-CXCL12 Tg mice

Strain information
Resource No. nbio317
Strain name villin-CXCL12 Tg
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6J
Institution Kyorin University (1), and EA Pharma (2)
Developer Tadakazu Hisamatsu (1), and Uo Michihide (2)
Depositor Tadakazu Hisamatsu (1), and Uo Michihide (2)
Conditions of distribution

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Animal Health Report
Strain description

Chronic inflamation characterized by infiltration of IgG-producing plasma cell into colonic mucosa is a histological hallmark of ulcerative coliteis. This infiltration is influenced by CXCL12-CXCR4 axis. CXCL12 is a CXC chemokine, which is involved in the chemoattraction of T cells. The strain is a transgenic mouse line that overexpresses mouse CXCL12 (SDF-1α) specifically in gastrointestinal epithelial cells under the control of mouse villin promoter. This strain is useful for functional stuideis of CXCL12 in the gastrointestinal epithelial cells.

Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals
Gene information
Mutation types transgenic
Gene symbol Cxcl12
Gene name chemokine (C-X-C motif) ligand 12
Genotyping information