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Strain Detail

Strain information
Resource No. nbio006
Strain name YPC
Strain Nomenclature
Common name/Synonyms Poor coat mice
Strain types inbred
Background strain
Institution National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)(formerly, National Institute of Health)
Developer Shigetoshi Kurosawa
Depositor
Conditions of distribution without conditions : contact us
Animal Health Report
Strain description Photo of YPC mice

YPC is a mutant strain established from a Swiss albino mouse colony, which shows thin and short hairs, wavy vibrissae, and poorly developed hair bulbs and dermal papillae, but structures of the epidermis, dermis, and the sebaceous glands are normal (ref.1).

Sequence analysis revealed a single C-to-A nucleotide substitution at nucleotide 1382 in the Sgk3/Sgkl/CISK gene, causing a nonsense mutation at codon 461 (ref.2). Sgk3 knockout mice also show defective hair follicle development (ref.3). Therefore, Sgk3 is thought to be related to hair follicle development and homeostasis. Phosphorylation of GSK3β at Ser9 and the nuclear accumulation of β-catenin were reduced in YPC hair follicle, suggesting that phosphorylation of GSK3β and WNT-β-catenin pathway takes part in the SGK3-dependent regulation of hair follicle development (ref.4).

YPC-B6 congenic mouse (nbio069) is produced by backcrossing to C57BL/6 strain, and the mouse is available from the bank.

References
  1. Kurosawa S, Ogura A, Koura M, Noguchi A, Noguchi Y, Yamamoto Y, Takano K. A histological study on the skin and hairs of PC (poor coat) mice. Exp. Anim. 1991 40(2): 259-261
  2. Masujin K, Okada T, Tsuji T, Ishii Y, Takano K, Matsuda J, Ogura A, Kunieda T. A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice. DNA Res. 2004 Dec 31;11(6):371-9.
  3. McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D. Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell. 2004 Sep;15(9):4278-88.
  4. Okada T, Ishii Y, Masujin K, Yasoshima A, Matsuda J, Ogura A, Nakayama H, Kunieda T, Doi K. The critical roles of serum/glucocorticoid-regulated kinase 3 (SGK3) in the hair follicle morphogenesis and homeostasis: the allelic difference provides novel insights into hair follicle biology. Am J Pathol. 2006 Apr;168(4):1119-33.
Resource information
Cryopreserved sperm In-house Genotype ypc/ypc
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype ypc/ypc
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types spontaneus mutation
Gene symbol Sgk3/Sgkl/CISK
Gene name Serum/glucocorticoid-regulated kinase 3, Serum and glucocorticoid-inducible kinase-like kinase, Cytokine-Independent Survival Kinase
Genotyping information