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Strain Detail: Zbp1 KO mice

Strain information
Resource No. nbio155
Strain name Zbp1 KO
Strain Nomenclature
Common name/Synonyms DAI KO mice
Strain types mutant
Background strain C57BL/6J Jcl
Institution Research Institute for Microbial Diseases, Osaka University
Developer Shizuo Akira
Depositor Shizuo Akira
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Zbp1 KO mice are knockout mice deleted Z-DNA binding protein 1 (Zbp1), also known as DNA-dependent activator of IFN-regulatory factors (DAI). When Zbp1 mouse was administered DNA vaccine, Effect of DNA vaccine was no difference in the case of wildtype mouse. Therefore, it's showed that Zbp1 isn't essential for Toll-like receptor (TLR) non-dependent DNA recognition, such as B-DNA or DNA vaccine. This strain is available for elucidation of immune diseases and action mechanism of DNA vaccine.
Reference(s)
  1. Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, and Akira S. (2008) TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451(7179):725-9. [PMID:18256672]
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Method
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Zbp1 (2010010H03Rik, Dai, mZaDLM)
Gene name Z-DNA binding protein 1, DNA-dependent activator of IFN-regulatory factors
Genotyping information Genotyping protocol for Zbp1 KO mice (pdf).