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Strain Detail: Ace2-KO mice

Strain information
Resource No. nbio388
Strain name Ace2-KO
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition
Developer Osamu Suzuki
Depositor Osamu Suzuki
Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Knockout mice of Angiotensin-converting enzyme 2 (Ace2). An entire coding sequence of the Ace2 gene on X chromosome in 57BL/6N mice was removed by CRISPR/Cas9 system using TAKE method with Cas9 proteins and two guide RNAs targeting 5’- and 3’-UTRs of the gene. These mice are useful for studies of hypertension and new coronaviruses. For example, it is possible to cross human Ace2-Tg mice (Ace2-Tg#5Ace2-Tg#16Ace2-Tg#17) with the Ace2-KO mice to produce mice whose Ace2 molecules are humans only.

Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
From other institutions Mating System
Strain status / Availability Cryopreserved sperm
Cryopreserved embryo
Live animals
Gene information
Mutation types Knockout
Gene symbol Ace2
Gene name Angiotensin-converting enzyme 2
Genotyping information Genotyping protocol for Ace2-KO mice (pdf).