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Strain Detail

Strain information
Resource No. nbio061
Strain name ADAMTS13 KO
Strain Nomenclature 129+Ter/SvJcl-TgH(Adamts13) NCVC
Common name/Synonyms
Strain types mutant
Background strain
Institution National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution It's necessary to obtain depositor's consent on use of biological resources. : contact us
Animal Health Report
Strain description

ADAMTS13 KO mice are deleted for ADAMTS13, a plasma protease which cleaves von Willebrand factor (VWF) specifically. These mice are useful model for the research about function of ADAMTS13 and thrombocytopenia.

It's known that little activity of ADAMTS13 is induced thrombotic thrombocytopenic purpura (TTP) in human. ADAMTS13 KO mice don't show TTP-like symptoms at least under the normal breeding though unusually large VWF multimer exists in plasma. It also considered that some additional factor is related to onset because ADAMTS13 KO mice show remarkable thrombocytopenia by intravenous administration of collagen, but not TTP.

The gene background of ADAMTS13 KO mice is 129+Ter/SvJcl. It's possible to supply B6 congenic mice produced by backcrossing to C57BL/6Cr [ADAMTS13 KO (C57BL/6Cr congenic), nbio074].

References
  1. Banno F, Kokame K, Okuda T, Honda S, Miyata S, Kato H, Tomiyama Y, Miyata T. Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura. Blood. 2006 Apr 15;107(8):3161-6. Epub 2005 Dec 20. (PMID: 16368888)
Resource information
Cryopreserved sperm In-house Genotype
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium EFS40
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live mouse
Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Adamts13
Gene name A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13
Genotyping information Genotyping PCR for Adamts13 KO mice in PDF format