HOME > mice > ADAMTS13L/L mice
Strain Detail
Strain information | |||
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Resource No. | nbio134 | ||
Strain name | ADAMTS13L/L | ||
Strain Nomenclature | C57BL/6CrSlc-Adamts13L/L NCVC | ||
Common name/Synonyms | |||
Strain types | congenic | ||
Background strain | |||
Institution | National Cerebral and Cardiovascular Center Research Institute | ||
Developer | Toshiyuki Miyata | ||
Depositor | Toshiyuki Miyata (Contact person: Koichi Kokame) | ||
Conditions of distribution | It's necessary to obtain depositor's consent on use of biological resources. : contact us | ||
Animal Health Report | |||
Strain description |
ADAMTS13L/L is established to introduce Adamts13 gene derived from 129/Sv strain into C57BL/6 strain by backcrossing. These mice express full-length ADAMTS13 (ADAMTS13L), whereas wildtype C57BL/6 mice express C-terminal domain deleted ADAMTS13 (ADAMTS13S) by the insertion of retrotransposon into Adamts13 gene. It's known that ADAMTS13 is a plasma protease which cleaves von Willebrand factor (VWF) specifically and deletion of ADAMTS13 activity is caused thrombotic thrombocytopenic purpura (TTP) in human. ADAMTS13S/S mice (nbio135) which are introduced Adamts13 gene derived from C57BL/6 strain into 129/Sv strain by backcrossing and express C-terminal domain deleted ADAMTS13 (ADAMTS13S) is also available. |
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Resource information | |||
Cryopreserved sperm | In-house | Genotype | |
Medium | FERTIUP | ||
From other institutions | Genotype | ||
Medium | |||
Cryopreserved embryo | In-house | Mating System | |
Genotype | |||
Medium | EFS40 | ||
From other institutions | Mating System | ||
Genotype | |||
Medium | |||
Strain status / Availability | Cryopreserved sperm | Within 1 month | |
Cryopreserved embryo | Within 1 month | ||
Live mouse |
Approx. 2 months | ||
Gene information | |||
Mutation types | |||
Gene symbol | Adamts13 | ||
Gene name | A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13 | ||
Genotyping information |