HOME > mice > ADAMTS13S/S mice
Strain Detail: ADAMTS13S/S mice
|Institution||National Cerebral and Cardiovascular Center Research Institute|
|Depositor||Toshiyuki Miyata (Contact person: Koichi Kokame)|
|Conditions of distribution||It's necessary to obtain depositor's consent on use of biological resources. contact us|
|Animal Health Report|
ADAMTS13S/Smice is established to introduce Adamts13 gene derived from C57BL/6 strain into 129/Sv strain by backcrossing. These mice express C-terminal domain deleted ADAMTS13 (ADAMTS13S) by the insertion of retrotransposon intoAdamts13gene., whereas wildtype 129/Sv mice express full-length ADAMTS13 (ADAMTS13L).
These mice are remarkable grade of thrombocytopenia caused by experimental collagen administration compared with ADAMTS13L expressed mice (wildtype 129/Sv), not so much as ADAMTS13 KO mice (nbio061,nbio074). Therefore, it's considered that C-terminal domain deletion of ADAMTS13 gives potential thrombosis risk to mice.
It's known that ADAMTS13 is a plasma protease which cleaves von Willebrand factor (VWF) specifically and deletion of ADAMTS13 activity is caused thrombotic thrombocytopenic purpura (TTP) in human.
ADAMTS13L/Lmice (nbio134) which are introduced Adamts13 gene derived from 129/Sv strain into C57BL/6 strain by backcrossing and express full-length ADAMTS13 (ADAMTS13L) is also available.
|From other institutions||Genotype|
|Cryopreserved embryo||In-house||Mating System|
|From other institutions||Mating System|
|Strain status / Availability||Cryopreserved sperm||Within 1 month|
|Cryopreserved embryo||Within 1 month|
|Live animals||Approx. 2 months|
|Gene name||A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13|