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Strain Detail: CK mice

Strain information
Resource No. nbio019
Strain name CK
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain
Institution National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)(formerly, National Institute of Infectious Diseases)
Developer Junichiro Matsuda
Conditions of distribution without conditions: contact us
Animal Health Report
Strain description

CK mice were established for research of GM1-gangliosidosis which is human neurological genetic disease. CG mouse is a transgenic mouse overexpressing human normal β-galactosidase (β-Gal) in whole body, which was developed to study GM1-gangliosidosis, a typical human neurological genetic disease. Transgenes are consisted of CAG promoter and human β-Gal cDNA. CG mice also express mouse endogenous β-Gal. CK mice were produced by introducing human normal β-Gal into β-Gal KO (BKO) mice. The CK mouse does not express mouse β-Gal but overexpresses human normal β-Gal. The mouse does not show neurologic symptoms or lipid accumulation.

Resource information
Cryopreserved sperm In-house Genotype Tg/+, β-Gal (+/-)
From other institutions Genotype
Cryopreserved embryo In-house Mating System
Genotype Tg/+, β-Gal (+/-), β-Gal (-/-)
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic + knockout
Gene symbol Glb1
Gene name Galactosidase, beta 1
Genotyping information