HOME > mice > Herp KO(B6J) mice
Strain Detail: Herp KO(B6J) mice
| Strain information |
| Resource No. |
nbio236 |
| Strain name |
Herp KO(B6J) |
| Strain Nomenclature |
C57BL/6J-Herpud1tmNCVC |
| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
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| Institution |
Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute |
| Developer |
Toshiyuki Miyata |
| Depositor |
Toshiyuki Miyata (Contact person: Koichi Kokame) |
| Conditions of distribution |
In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
Herp KO(B6J) mice are knockout mice for the Herpud1 gene. These mice are born normally according to Mendelian inheritance. In organs, such as the liver, the expression levels of ER-associated degradation (ERAD) related proteins were affected under both normal and ER stress conditions. These mice also show decreased ERAD substrate degradation in the liver, the disorder of glucose tolerance, and the reduction of resistance for cerebral ischemia. This strain is expected a useful model to elucidate the relationship between ERAD and stress or pathologic conditions. Herpud1 is an endoplasmic reticulum membrane protein induced by ER stress. This strain has C57BL/6JJcl(Nnt+/+) background. We also supply Herp KO(B6N) mice (nbio242), which have C57BL/6NCrSlc background. |
| Reference(s) |
- Eura Y, Yanamoto H, Arai Y, Okuda T, Miyata T, Kokame K. Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One. 2012;7(3):e34298.
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
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| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
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| Genotype |
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| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
knockout |
| Gene symbol |
Herpud1 |
| Gene name |
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
| Genotyping information |
Genotyping PCR for HerpKO(B6J) in PDF format |
