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Strain Detail: Herp KO(B6J) mice

Strain information
Resource No. nbio236
Strain name Herp KO(B6J)
Strain Nomenclature C57BL/6J-Herpud1tmNCVC
Common name/Synonyms
Strain types mutant
Background strain
Institution Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute
Developer Toshiyuki Miyata
Depositor Toshiyuki Miyata (Contact person: Koichi Kokame)
Conditions of distribution In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. contact us
Animal Health Report
Strain description

Herp KO(B6J) mice are knockout mice for the Herpud1 gene. These mice are born normally according to Mendelian inheritance. In organs, such as the liver, the expression levels of ER-associated degradation (ERAD) related proteins were affected under both normal and ER stress conditions. These mice also show decreased ERAD substrate degradation in the liver, the disorder of glucose tolerance, and the reduction of resistance for cerebral ischemia. This strain is expected a useful model to elucidate the relationship between ERAD and stress or pathologic conditions. Herpud1 is an endoplasmic reticulum membrane protein induced by ER stress. This strain has C57BL/6JJcl(Nnt+/+) background. We also supply Herp KO(B6N) mice (nbio242), which have C57BL/6NCrSlc background.

  1. Eura Y, Yanamoto H, Arai Y, Okuda T, Miyata T, Kokame K. Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One. 2012;7(3):e34298.
Resource information
Cryopreserved sperm In-house Genotype
From other institutions Genotype
Cryopreserved embryo In-house Mating System
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types knockout
Gene symbol Herpud1
Gene name homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Genotyping information Genotyping PCR for HerpKO(B6J) in PDF format