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Strain Detail: mTSN Tg#8

Strain information
Resource No. nbio272
Strain name mTSN Tg#8
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6JJmsSlc
Institution Department of Immunology, National Institute of Infectious Deseases
Developer Masataka Kasai
Depositor Masataka Kasai
Conditions of distribution

In publishing the research results obtained by use of the animal resource, a citation of the following literature and the stipulation of an acknowledgment to depositor designated by the depositor is requested. It's necessary to obtain depositor's consent on use of biological resources. contact us

Animal Health Report
Strain description

The mTSN Tg#8 mice are transgenic mice expressing CAG-promoter-driven mouse translin (TSN) in the whole body. The translin gene encodes a protein which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies. In the native form, translin polypeptides form a multimeric structure (octamer) which is responsible for its DMA binding activity. A study using TSN deficient mice indicated that the TSN is involved in the blood formation in the bone marrow by regulating differentiation of mesenchymal stem cells (MSC). The strain is useful for research in MSC and hematopoietic stem cell (HSC). Two lines (Tg#2 and Tg#8) are available.

References
  1. Aoki, K., Suzuki, K., Sugano, T., Nakahara, K., Kuge, O., and Kasai, M. A novel gene, Translin, encodes a Recombination Hotspot Binding Proteinassociated with Chromosomal Translocations in Human Lymphoid Neoplasms. Nature Genetics 10, 167-174 (1995)
  2. Ishida R, Aoki K, Nakahara K, Fukuda Y, Ohhori M, Saito Y, Kano K, Matsuda J, Asano S,Maziarz RT, Kasai M. Translin/TRAX deficiency affects mesenchymal differentiation programs and induces bone marrow failure. Stem Cells and Human Diseases (Springer-Verlag, Chapter 21 p468-476, 2012).
Resource information
Cryopreserved sperm In-house Genotype Tg/+
Medium FERTIUP
From other institutions Genotype
Medium
Cryopreserved embryo In-house Mating System
Genotype
Medium
From other institutions Mating System
Genotype
Medium
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo
Live mouse Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Tsn
Gene name Translin
Genotyping information