SIK3-KO mice are knockout mice of SIK3, a protein kinase which belong to AMP dependent protein kinase (AMPK) family. Salt Inducible Kinase (SIK) is isolated from adrenal gland of rat fed high salt containing food as a factor about control of aldosterone synthesis. It has three isoforms, SIK1, SIK2, SIK3. This strain is available for research of carbohydrate or liqid metabolism. In future, we are going to start to supply SIK3-KO mice in KK-Ay background. Incidentally, it's possible to supplySIK2-KO mice (nbio071).
- Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii M, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H. Involvement of SIK3 in glucose and lipid homeostasis in mice. PLoS ONE (2012) 7 e37803. [PMID: 22662228]
- Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H, Tsumaki N. SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development (2012) 139: 1153-63. [PMID: 22318228]