HOME > mice > ShDock6 Tg line #2 mice
Strain Detail: ShDock6 Tg line #2 mice
| Strain information |
| Resource No. |
nbio256 |
| Strain name |
ShDock6 Tg line #2 |
| Strain Nomenclature |
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| Common name/Synonyms |
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| Strain types |
mutant |
| Background strain |
C57BL/6J Jms |
| Institution |
National Research Institute for Child Health and Development, Department of Pharmacology |
| Developer |
Junji Yamauchi |
| Depositor |
Junji Yamauchi |
| Conditions of distribution |
Collaboration with the depositor only. In publishing the research results obtained by use of the biological resource, a citation of the following literature (ref. 1) and the stipulation of an acknowledgment to depositor are requested. It's necessary to obtain depositor's consent on use of biological resources. contact us |
| Animal Health Report |
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| Strain description |
The ShDock6 Tg mice are knockdown mice for Dock6 gene, harboring a transgene encoding short-hairpin (sh) RNA to produce small interfering RNA for Dock6. Dock6 is a guanine nucleotide exchange factor (GEF) that activates the Rho family guanosine triphosphatases Rac1 and Cdc42 to regulate the actin cytoskeleton. Study using the mice showed that the Dock6 is involved in the control of axon growth and regeneration of sensory neurons. The ShDock6 Tg mice are normally fertile under standard breeding conditions. Two lines (ShDock6 Tg #1 and ShDock6 Tg #2) are available. |
| Reference(s) |
- Miyamoto Y, Torii T, Yamamori N, Ogata T, Tanoue A, and Yamauchi J. (2013) Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons. Sci Signal 6(265):ra15. [PMID:23462102]
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| Resource information |
| Cryopreserved sperm |
In-house |
Genotype |
Tg/+ |
| Medium |
FERTIUP |
| From other institutions |
Genotype |
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| Medium |
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| Cryopreserved embryo |
In-house |
Mating System |
IVF |
| Genotype |
Tg/+ and Wild type |
| Medium |
EFS40 |
| From other institutions |
Mating System |
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| Genotype |
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| Method |
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| Strain status / Availability |
Cryopreserved sperm |
Within 1 month |
| Cryopreserved embryo |
Within 1 month |
| Live animals |
Approx. 2 months |
| Gene information |
| Mutation types |
transgenic |
| Gene symbol |
Dock6 |
| Gene name |
dedicator of cytokinesis 6 |
| Genotyping information |
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