HOME > mice > PGC-1α-c/A-line mice

Strain Detail: PGC-1α-c/A-line mice

Strain information
Resource No. nbio301
Strain name PGC-1α-c/A-line
Strain Nomenclature
Common name/Synonyms
Strain types mutant
Background strain C57BL/6N
Institution Department of Food Nutritional Science, University of Shizuoka
Developer Shinji Miura
Depositor Shinji Miura
Conditions of distribution

Only for collaboration with the depositor. contact us

Animal Health Report
Strain description

Three mRNA isoforms (PGC-1α-a, -b, and -c) are transcribed from PGC-1α (Ppargc1a) gene. Slightly different proteins are translated from the three mRNA isoforms. Expression of each isoform is different depending on tissue types and stimuli. Exercise increases PGC-1α-b and PGC-1α-c mRNAs, but not PGC-1α-a mRNA, in the skeletal muscle. On the other hand, fasting increased PGC-1α-a mRNA, but not PGC-1α-b or PGC-1α-c mRNAs, in the liver.

The PGC-1α-c/A-line is a transgenic mouse line with skeletal-muscle-specific (driven by human α-actin promotor) overexpression of PGC-1α-c mRNA (derived from the line 04-6 in Table 1 of Ref. 1). This strain is useful for studying isoform-specific functions of PGC-1&alpha mRNAs and proteins in skeletal muscles.

Multiple sublines overexpressing each isoform in skeletal muscles are available: three sublines (nbio095, nbio096, and nbio097) for PGC-1α-a, two sublines (nbio299, and nbio300) for PGC-1α-b, and three sublines (nbio301, nbio302, and nbio303) for PGC-1α-c.

  1. Miura S, Kai Y, Kamei Y, and Ezaki O. (2008) Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mRNA in response to β2-adrenergic receptor activation and exercise. Endocrinology 149(9):4527-33. [PMID:18511502]
Resource information
Cryopreserved sperm In-house Genotype Heterozygous
From other institutions Genotype
Cryopreserved embryo In-house Mating System IVF
Genotype mix of KO/+ and wild-type
Medium EFS40
From other institutions Mating System
Strain status / Availability Cryopreserved sperm Within 1 month
Cryopreserved embryo Within 1 month
Live animals Approx. 2 months
Gene information
Mutation types transgenic
Gene symbol Ppargc1a(PGC-1α)
Gene name Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Genotyping information